ARTRITIS SERONEGATIVA PDF

Zulugrel Sarcoidosis presenting as seronegative spondyloarthropathy Rev Esp Reumatol, 26pp. Are you a health professional able to prescribe or dispense drugs? Is rheumatoid arthritis hereditary? Ann Rheum Dis, 40pp.

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Tenderness Difficulty moving the joint It is common in advanced arthritis for significant secondary changes to occur. Disability Arthritis is the most common cause of disability in the USA. More than 20 million individuals with arthritis have severe limitations in function on a daily basis.

Arthritis can make it very difficult for individuals to be physically active and some become home bound. Each year, arthritis results in nearly 1 million hospitalizations and close to 45 million outpatient visits to health care centers.

Please help improve this section by adding citations to reliable sources. Unsourced material may be challenged and removed. January Learn how and when to remove this template message Diagnosis is made by clinical examination from an appropriate health professional, and may be supported by other tests such as radiology and blood tests, depending on the type of suspected arthritis.

Pain patterns may differ depending on the arthritides and the location. Rheumatoid arthritis is generally worse in the morning and associated with stiffness; in the early stages, patients often have no symptoms after a morning shower.

Osteoarthritis, on the other hand, tends to be worse after exercise. In the aged and children, pain might not be the main presenting feature; the aged patient simply moves less, the infantile patient refuses to use the affected limb. Important features are speed and time of onset, pattern of joint involvement, symmetry of symptoms, early morning stiffness, tenderness, gelling or locking with inactivity, aggravating and relieving factors, and other systemic symptoms.

Physical examination may confirm the diagnosis, or may indicate systemic disease. Radiographs are often used to follow progression or help assess severity.

Blood tests and X-rays of the affected joints often are performed to make the diagnosis. Screening blood tests are indicated if certain arthritides are suspected. These might include: rheumatoid factor, antinuclear factor ANF , extractable nuclear antigen, and specific antibodies. Osteoarthritis Main article: Osteoarthritis Osteoarthritis is the most common form of arthritis. The disease is essentially one acquired from daily wear and tear of the joint; however, osteoarthritis can also occur as a result of injury.

In recent years[when? Osteoarthritis begins in the cartilage and eventually causes the two opposing bones to erode into each other. The condition starts with minor pain during physical activity, but soon the pain can be continuous and even occur while in a state of rest. The pain can be debilitating and prevent one from doing some activities.

Osteoarthritis typically affects the weight-bearing joints, such as the back, knee and hip. Unlike rheumatoid arthritis, osteoarthritis is most commonly a disease of the elderly. More than 30 percent of women have some degree of osteoarthritis by age Risk factors for osteoarthritis include prior joint trauma, obesity, and a sedentary lifestyle. The attack is not only directed at the joint but to many other parts of the body.

In rheumatoid arthritis, most damage occurs to the joint lining and cartilage which eventually results in erosion of two opposing bones. RA often affects joints in the fingers, wrists, knees and elbows, is symmetrical appears on both sides of the body , and can lead to severe deformity in a few years if not treated. RA occurs mostly in people aged 20 and above. In children, the disorder can present with a skin rash, fever, pain, disability, and limitations in daily activities.

With earlier diagnosis and aggressive treatment, many individuals can lead a better quality of life than if going undiagnosed for long after RA s onset. The drugs to treat RA range from corticosteroids to monoclonal antibodies given intravenously. Treatments also include analgesics such as NSAIDs and disease-modifying antirheumatic drugs DMARDs , while in rare cases, surgery may be required to replace joints, but there is no cure for the disease.

Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts.

One of the main triggers of bone erosion in the joints in rheumatoid arthritis is inflammation of the synovium, caused in part by the production of pro-inflammatory cytokines and receptor activator of nuclear factor kappa B ligand RANKL , a cell surface protein present in Th17 cells and osteoblasts.

Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it can occur in many joints and be quite crippling.

The joints in gout can often become swollen and lose function. Gouty arthritis can become particularly painful and potentially debilitating when gout cannot successfully be treated. It presents with sudden onset of chills, fever and joint pain. The condition is caused by bacteria elsewhere in the body.

Infectious arthritis must be rapidly diagnosed and treated promptly to prevent irreversible joint damage. With psoriatic arthritis, most individuals develop the skin problem first and then the arthritis.

The typical features are of continuous joint pains, stiffness and swelling. The disease does recur with periods of remission but there is no cure for the disorder. A small percentage develop a severe painful and destructive form of arthritis which destroys the small joints in the hands and can lead to permanent disability and loss of hand function.

Treatment options vary depending on the type of arthritis and include physical therapy, lifestyle changes including exercise and weight control , orthopedic bracing, and medications. Joint replacement surgery may be required in eroding forms of arthritis. Medications can help reduce inflammation in the joint which decreases pain. Moreover, by decreasing inflammation, the joint damage may be slowed.

Furthermore, exercise of the arthritic joint is encouraged to maintain the health of the particular joint and the overall body of the person. In arthritis the joints become stiff and the range of movement can be limited. Physical therapy has been shown to significantly improve function, decrease pain, and delay need for surgical intervention in advanced cases.

Exercise often focuses on improving muscle strength, endurance and flexibility. In some cases, exercises may be designed to train balance. Occupational therapy can provide assistance with activities as well as equipment.

Treatment typically begins with medications that have the fewest side effects with further medications being added if insufficiently effective. For example, the first-line treatment for osteoarthritis is acetaminophen paracetamol while for inflammatory arthritis it involves non-steroidal anti-inflammatory drugs NSAIDs like ibuprofen. An example of this type of drug is methotrexate. Surgery A number of rheumasurgical interventions have been incorporated in the treatment of arthritis since the s.

Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and medical therapy. With an aging population, this number is expected to increase. Of these, osteoarthritis is the fastest increasing major health condition. A systematic review assessed the prevalence of arthritis in Africa and included twenty population-based and seven hospital-based studies. Nine studies were well-conducted, eleven studies were of moderate quality, and seven studies were conducted poorly.

The results of the systematic review were as follows: Rheumatoid arthritis: 0. In early reports, arthritis was frequently referred to as the most common ailment of prehistoric peoples.

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